Interleukin 35<\/h3>
IL-35 is a dimeric protein composed of IL-12\u03b1 and IL-27\u03b2 chains, which are encoded by two separate genes called IL12A and EBI3, respectively.[1] IL-35 receptor consists of IL-12R\u03b22 (part of the IL-12R) and gp130 (part of IL-27R) chains. Compared to these two related interleukins, IL-35 is also able to signal through only one of the aforementioned chains. This was proven in vivo when absence of either of the receptor chains did not influence effects of IL-35.[2]<\/p>
Secreted by regulatory T-cells (Tregs), regulatory B-cells (Bregs)[3] or even CD8+ regulatory T cells,[4] IL-35 suppresses inflammatory responses of immune cells.[5] IL-35 is not constitutively expressed in tissues, but the gene encoding IL-35 is transcribed by vascular endothelial cells, smooth muscle cells and monocytes after activation with proinflammatory stimuli.[6] IL-35 has selective activities on different T-cell subsets; it induces proliferation of Treg cell populations but reduces activity of Th17 cell populations.[7]<\/p>
Studies in mice show the absence of either IL-35 chain from regulatory Tregs reduces the cells' ability to suppress inflammation. This has been observed during cell culture experiments and using an experimental model for inflammatory bowel disease.[8] A group of scientists established a CIA (collagen-induced arthritis) mouse model to show suppressive effects of IL-35. Intraperitoneal injection of IL-35 in the tested subjects lowered expression of several factors linked to this disease (such as VEGF and its receptors, TNF-\u03b1).[9] The effect of IL-35 in this case seems to be the inhibition of STAT1 signalling pathway.[10] Another experiment performed on a mouse model of EAE has shown, that mice lacking IL-35-producing B cells are unable to recover from the T-cell mediated demyelination but are resistant to infection by pathogenic intracellular microbe Salmonella typhimurium.[11]<\/p><\/div>\n
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Business Results 1 - 10 <\/strong>of 34<\/h4>\n\t\t\t\t
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Alexz Nails & Spa<\/span><\/strong><\/div>\n\t\t\t\t 3<\/span> Reviews <\/div><\/div>\n\t\t\t\tNail SalonsPhone: <\/span><\/div>\n\t\t\t\t\n\t\t\t\t3347 1\/2 N Vermilion St, Danville, IL 61832\n\t\t\t\t<\/span><\/div>\n<\/div><\/div><\/div>
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Studio 31 Salon & Spa<\/span><\/strong><\/div>\n\t\t\t\t 1<\/span> Reviews <\/div><\/div>\n\t\t\t\tDay SpasPhone: <\/span><\/div>\n\t\t\t\t\n\t\t\t\t11 E Liberty Ln, Danville, IL 61832\n\t\t\t\t<\/span><\/div>\n<\/div><\/div><\/div>
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Iron Tide Gallery<\/span><\/strong><\/div>\n\t\t\t\t 4<\/span> Reviews <\/div><\/div>\n\t\t\t\tTattooPhone: <\/span><\/div>\n\t\t\t\t\n\t\t\t\t419 N Gilbert St, Danville, IL 61832\n\t\t\t\t<\/span><\/div>\n<\/div><\/div><\/div>
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Kevin & Co<\/span><\/strong><\/div>\n\t\t\t\t 1<\/span> Reviews <\/div><\/div>\n\t\t\t\tHair SalonsPhone: <\/span><\/div>\n\t\t\t\t\n\t\t\t\t3607 N Vermilion St, Ste 3, Danville, IL 61832\n\t\t\t\t<\/span><\/div>\n<\/div><\/div><\/div>
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Sally Beauty Supply<\/span><\/strong><\/div>\n\t\t\t\t 1<\/span> Reviews <\/div><\/div>\n\t\t\t\tCosmetics & Beauty SupplyPhone: <\/span><\/div>\n\t\t\t\t\n\t\t\t\t22 E West Newell Rd, Ste F, Danville, IL 61834\n\t\t\t\t<\/span><\/div>\n<\/div><\/div><\/div>
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Escape Hair & Body Spa<\/span><\/strong><\/div>\n\t\t\t\t 3<\/span> Reviews <\/div><\/div>\n\t\t\t\tNail SalonsPhone: <\/span><\/div>\n\t\t\t\t\n\t\t\t\t905 Sherman St, Danville, IL 61832\n\t\t\t\t<\/span><\/div>\n<\/div><\/div><\/div>
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Redwood's New Heights For Hair & Nails<\/span><\/strong><\/div>\n\t\t\t\t 1<\/span> Reviews <\/div><\/div>\n\t\t\t\tBarbersPhone: <\/span><\/div>\n\t\t\t\t\n\t\t\t\t633 Warrington Ave, Danville, IL 61832\n\t\t\t\t<\/span><\/div>\n<\/div><\/div><\/div>
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Style FX Salon & Tanning<\/span><\/strong><\/div>\n\t\t\t\t 1<\/span> Reviews <\/div><\/div>\n\t\t\t\tHair Salons, TanningPhone: <\/span><\/div>\n\t\t\t\t\n\t\t\t\t105 E Sangamon Ave, Rantoul, IL 61866\n\t\t\t\t<\/span><\/div>\n<\/div><\/div><\/div>
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Tee Nails & Spa<\/span><\/strong><\/div>\n\t\t\t\t 3<\/span> Reviews <\/div><\/div>\n\t\t\t\tNail Salons, WaxingPhone: <\/span><\/div>\n\t\t\t\t\n\t\t\t\t2715 N Vermilion St, Danville, IL 61832\n\t\t\t\t<\/span><\/div>\n<\/div><\/div><\/div>
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Shear Excellence Salon<\/span><\/strong><\/div>\n\t\t\t\t 2<\/span> Reviews <\/div><\/div>\n\t\t\t\tMassage, Skin Care, Hair SalonsPhone: <\/span><\/div>\n\t\t\t\t\n\t\t\t\t1281 E Grove Ave, Rantoul, IL 61866\n\t\t\t\t<\/span><\/div>\n<\/div><\/div>